8% of hysteroscopies and in 56. This is done to evaluate infertility or dysmenorrhea. What does this mean? endometrium, biopsy: disordered proliferative endometrium with associated simple (cystic) hyperplasia. 2023 Feb 1;141 (2):265-267. 2 Proliferative Endometrium4,572 satisfied customers. Disordered proliferative endometrium is a non-cancerous change that develops in the tissue that lines the inside of the uterus. It is a special type of tissue that helps hold the other parts of the organ together. This test is also used to identify uterine infections, such as endometritis . Weakly proliferative endometrium shows a pattern intermediate between normal proliferative and atrophic. It's a long-term condition that can have a significant impact on your life, but there are treatments that can help. At this. There was one case who was a 75-years-old woman presenting with both deep infiltrating endometriosis in bladder and small bowel and adenomyosis lesions, but her endometrium was weakly proliferative. Endometrial carcinomas account for the greatest number of these cases, as fewer than 10% of uterine corpus cancers are sarcomas. The endometrial. Dr. What does this mean?Endometrial biopsy:benign proliferative endometrium with ciliated cell metaplasia without hyperplasia or malignancy. In the present pictorial review, we briefly discuss the various morphologic. 3%) 'gland crowding' cases were identified, in which 69% (143/206) had follow-up sampling. SEE COMMENT. •ICCR definition:-REQUIRED ELEMENTS- those which are unanimously agreed by the panel to be essential for the histological diagnosis, clinical. Endometrial hyperplasia (EH) is a spectrum of morphological changes ranging from a slightly disordered pattern seen in the late proliferative phase of the menstrual cycle to the irregular proliferation of the endometrial glands with an increase in gland-to-stroma ratio leading to thickening of the endometrium []. This refers to: Build up of the uterine lining, as would happen in the cycle prior to ovulation (egg release) to prepare for implantation of the fertilized egg. Share. Lindemann. Disordered proliferative endometrium with glandular and stromal breakdown. Metaplasia is defined as a change of one cell type to another cell type. Only in postmenopaus: The endometrium is the lining of the uterus, and it 'proliferates' during the 1st 1/2 of the menstrual cycle under the influence of the estrogen that. 2 vs 64. read more. Re: Disordered Proliferative Endometrium. 1 The American College of Obstetricians and Gynecologists (ACOG) recommends endometrial tissue sampling in any woman with abnormal uterine bleeding who is older than 45 years, or in. 3k views Reviewed >2 years ago. Learn how we can help. Dr. Personal hx colorectal cancer Endometrial polyp Morbid obesity Presence of one or more factors, increases risk by 8 times. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE ENDOMETRIUM WITH FOCAL STROMAL AND/OR GLANDULAR BREAKDOWN. Compact. The endometrium is normal proliferative phase in which buds of small morules were scattered (Figure 1C). The risk. 5 years; P<. Relatively normal gland to stroma ratio (glands occupy < 50% of the. Cardiovascular surgeon. Endometrial Polyp B. This is healthy reproductive cell activity. An introduction to the endometrium is found in the endometrium article. Disordered proliferative endometrium with glandular and. Abstract. 4 It is a disease of ageing, with over 80% of cases occurring during the. and 200 cases of endometrial samples with typical tubal metaplasia were followed for a mean of 64 and 61 months, respectively. The degree of proliferation can vary in proportion to the estrogenic stimulus. Definition A proliferative endometrium is a normal part of healthy. FRAGMENTS OF BENIGN ENDOCERVICALTISSUE. For good health - Have a diet rich in fresh vegetables, fruits, whole grains, milk and milk products, nuts, beans, legumes, lentils and small amounts. What does this mean? waiting to hear from doctor. resembling proliferative phase endometrium. Similar to the cells normally found in the fallopian tube, the cells often have small hair-like projections called cilia. 4) and their mean BMI was 31. 5 ±17. 3. Harold Fields answered. Most women (90%) with endometrial cancer develop symptomatic vaginal bleeding or discharge, and this is often what prompts them to seek gynecologic care. Endometrial hyperplasia is an abnormal proliferative response to estrogenic stimulation. Results: All postmenopausal endometria were atrophic, but only 42 were inactive; of the remaining samples, 22 were weakly proliferative and 20 were mixed active and inactive. 5. 100 endometrial biopsies were selected, excluding specimens with limited material, cancer and menstrual phase. A hysterectomy makes it impossible for you to become pregnant in the future. Is this a diagnosable condition? Proliferative endometrium isn't a symptom or condition. Learn how we can help. Adenomyosis is a benign uterine disorder in which endometrial glands are found in the myometrium of the uterus. Consider hormonal management or an. Created for people with ongoing healthcare needs but benefits everyone. There were some proliferative endometria with cystically dilated glands that were indistinguishable from a disordered proliferative, or anovulatory, endometrium. Wendy Askew answered. Van den Bosch et al 11 found that 14. 3); it is important to realize that secretory material within glandular lumina is not specific to secretory endometrium but may also. 5. Definition. The uterus is a muscular, pear-shaped, hollow organ that forms an important part of the. N85. The specimens were all from patients with dysfunctional uterine bleeding and include 30 poorly active endometrium, 16 atrophic endometrium, 2 weakly proliferative endometrium, 3 disordered. 6k views Reviewed Dec 27, 2022. Endometrial hyperplasia (EH) is a pre-cancerous, non-physiological, non-invasive proliferation of the endometrium that results in increased volume of endometrial tissue with alterations of glandular architecture (shape and size) and endometrial gland to stroma ratio of greater than 1:1 [5,6]. A proliferative endometrium in itself is not worrisome. Introduction. 0001). Hysteroscopy is now considered the standard diagnostic tool. In contrast, the non-neoplastic component of 43 of the 50 endometrial adenocarcinomas examined was of the active form; four specimens were of the pure and 39 of the mixed. 00524, p <0. I was diagnosed with disordered proliferative endometrium with glandular and stromal breakdown, benign polyps simple hyperplasia w/o atypia, a fibroid size of grapefruit pressing on bladder. The aim of this review is to update current issues and provide a classification with a practical clinicopathological approach. (tend to diagnose disordered proliferative endometrium in perimenopausal years) •occasional dilated glands with proliferative activity, stromal breakdown, metaplasias (especially ciliated). Of the 142 specimens, 59 (41. Frequent, unpredictable periods whose lengths and heaviness vary. If left untreated, disordered proliferative endometrium can change into another non-cancerous condition called endometrial hyperplasia. Demosthenes, MD. satisfied customers. Decidua and decidualization redirect to this article. (47). 0001) and had a higher body mass index (33. Approximately 20% of postmenopausal patients have endometrial pathology. Created for people with ongoing healthcare needs but benefits everyone. Definition/Introduction. Ciliated cell changes (tubal metaplasia) is an early change. focal mucinous metaplasia. Screening for endocervical or endometrial cancer. 5 years; P<. Normal : It's benign tissue that shows estrogen effect (proliferative endometrium ), cell changes that are benign (ciliated metaplasia) & no precancerous or cancerous cells. Decidualized endometrium is endometrium with changes due to progestins. Dilated glands usually with irregular shape (branched, convoluted, scalloped outer contours) > 10% of overall glands. Women with a proliferative endometrium were younger (61. 100 endometrial biopsies were selected, excluding specimens with limited material, cancer and menstrual phase. They constitute less than 10% of all uterine malignancies and approximately 20% of all uterine sarcomas. Uterine polyp and endometrial polyp redirect here. The 2024 edition of ICD-10-CM N85. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE ENDOMETRIUM WITH FOCAL STROMAL AND/OR GLANDULAR BREAKDOWN. Endometrial cancer is sometimes called uterine cancer. The endometrium, a tissue of continuously changing patterns and immense proliferative activity during a woman’s reproductive life, becomes atrophic after the menopause as a result of ovarian failure. I had a biopsy with a d and c 15 weeks ago that was returned benign, negative for hyperplasia and carcinoma. Note that when research or. Eosinophilic and Ciliated Cell Metaplasia in Endometrium is a type of metaplasia noted in the uterine corpus. Conditions that involve the endometrium and may impact fertility include: Adenomyosis. Introduction. Cancer can affect the uterus, the hollow, pear-shaped organ where a baby grows. Endometrium in proliferative phase, secretory phase, endometrial polyps, and disordered proliferative endometrium were studied for the presence of plasma cells. 10170. 3% had actively proliferative endometrial histology, and 0. Europe PMC is an archive of life sciences journal literature. While embryo development and endometrial preparation are concurrent yet independent processes, their synchronization is critical to the success of embryo apposition, adhesion, invasion, and further ongoing. The unstained glands are irregularly dispersed with focal back-to-back crowding. 5), with loss of distinction between the basal and functional layer; (b) proliferative type endometrial glands, somewhat tortuous, with tall columnar pseudostratified epithelium, oval. This is the American ICD-10-CM version of N85. 2 weakly proliferative endometrium, 3 disordered prolifera-tive. It is also simply known as endometrial polyp which is a somewhat ambiguous descriptor as not all endometrial polyps are benign. Normal cyclical endometrium showed patchy glandular staining and there was also focal stromal p16 expression in the functional layer of most proliferative and secretory endometria. Endometrial carcinoma is the most common invasive neoplasm of the female reproductive tract. (b) On CD10 immunohistochemistry, the stroma stains positive, confirming endometrial-type stroma, while the endometrial glands are negative. « lining in uterus thickened | Cells from uterus that show up in a pap ». The endometrium from a woman being treated with unopposed estrogens will most commonly appear proliferative, and may in fact be indistinguishable from a normal proliferative endometrium in a premenopausal patient. During the menstrual cycle, the endometrium grows under the influence of two major hormones estrogen and progesterone. Signs and symptoms of uterine polyps include: Vaginal bleeding after menopause. tubal/eosinophil hyperpla A Verified Doctor answered Dr. 9. This book chapter provides an overview of the epidemiology, risk factors, diagnosis, staging, and treatment of endometrial cancer, as well as the latest research and guidelines. X. Mixed: The mixed form of endometrium is defined as atrophic and inactive endometria showing focal areas of weakly proliferative glands. 186 satisfied customers. 9 vs 30. Benign endometrial polyp, abbreviated BEP, is a common diagnosis in endometrial specimens. During the menstrual cycle, the endometrium grows under the influence of two major hormones – estrogen and progesterone. • 01-2021 Vaginal Ultrasound: Showed 3 fibroids, endometrium lining 8. People who have atypical endometrial hyperplasia have a higher risk of developing uterine cancer. (n=46) for 3 months. Microscopic findings. What does weakly proliferative endometrium mean. TABLE 1: 2012 Summary of Physician Office Endometrial Biopsy Specimens Diagnosis Number of Cases Percentage of Cases Proliferative Endometrium 239 23. About 3. during your monthly. 6 kg/m 2; P<. Conclusions: At least half of the disease free postmenopausal atrophic endometria show a weak proliferative pattern, either diffuse or focal, probably as a response to continuous. Dr. Normal: This is a normal thickening of the female sexual mucous and often indicates a fertime time of the month. Weakly proliferative endometrium does not denote a specific functional state but is better conceptualized as a morphologic pattern. I'm 51, no period 8 months, spotting almost every day for year. May be day 5-13 - if the menstruation is not included. Does proliferative endometrium mean cancer? No. stroma. Plasma cells are commonly present in the endometrium of women with dysfunctional uterine bleeding and. Thank. "37yo, normal cycles, has one child, trying to conceive second. Specimen A-FRAGMENTED WEAKLY PROLIFERATIVE ENDOMETRIUM, Specimen A-FRAGMENTED WEAKLY PROLIFERATIVE ENDOMETRIUM, SHOWING STROMAL AND GLANDULAR. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE. The basic effect of estrogens on the endometrium is to induce proliferation of the endometrial glands and stroma, including vascular endothelium. This is called the proliferative phase because the endometrium (the lining of the uterus) becomes thicker. Unremarkable squamous epithelium is also normal and mucus is a normal finding. Endometriosis often involves the pelvic tissue. It can be healthy or disordered depending on the rate of cell growth and shedding. 7. The significance of the findings is that the metaplasia may present. Figure 1. Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. Adenomyosis is distinct from endometriosis, which is the presence of endometrial. What does atrophic endometrium mean? Atrophic endometrium is a non-cancerous change that occurs in the tissue lining the inside of the uterus. Endometriosis. Gurmukh Singh answered. 2 mm thick (mean, 2. Effect of estrogen: Complicated, so one's ob - gyn doctor can give individual recommendations. Endometriosis is a condition in which cells similar to the lining of the uterus, or endometrium, grow outside the uterus. Results: After intervention in letrozole group, response to treatment was seen in 93% cases (including endometrial atrophy in 58. is this something t?" Answered by Dr. Read More. Hysteroscopy combined with biopsy increases the accuracy of diagnosis up to 100%. . Proliferative endometrium is a noncancerous (benign) and normal cause of thickening seen on an ultrasound. DDx. Dr. No cancer: Depending on the time of your menstrual cycle, it is a normal finding. Diagnosis: Diagnosis: Fragments of weakly proliferative/inactive endometrium. A weakly proliferative endometrium with focal stromal breakdown typically indicates that the endometrial lining of the uterus is not thickening as it should during the menstrual cycle. 4 It is a disease of ageing, with over 80% of cases occurring during the. No malignancy was recognized. 6% in postmenopausal patients, 91% in premenopausal patients, and 81% for EIN. The stromal cells are arranged in a compact manner. 2 vs 64. - Negative for. Many of these cells are called fibroblasts and pathologists often describe them as spindle cells because they are long. At the same time, menopausal endometrium is. Obstetrics and Gynecology 29 years experience. In proliferative endometrium, the level of expression was increased, but still much less than those seen in the malignant epithelial cells. ICD-10-CM Coding Rules. SEE COMMENT. 8% of hysteroscopies and in 56. Keywords: endometrium, atrophic, inactive, weakly proliferative, endometrial adenocarcinoma. A repeat "d&c after ablation " is usually not going to produce different results. Endometrial stromal tumors (ESTs) are rare mesenchymal tumors occurring primarily in the uterine corpus. Endometrium at menopause is inactive and free of cyclical changes that are characteristics of the reproductive age. 8 is applicable to female patients. Doctor's Assistant: When was your last pap smear? Have you ever had an irregular pap? My pap was good clinical history is abnormal uterine bleeding. thank you endometrium, biopsy: -glandular and stromal breakdown, consistent with bleeding changes -negative for atypia or malignancy?. 0; range, 1. While embryo development and endometrial preparation are concurrent yet independent processes, their synchronization is critical to the success of embryo apposition, adhesion, invasion, and further ongoing. proliferative endometrium: Endometrial hypertrophy due to estrogen stimulation during the preovulatory phase of the menstrual cycle. Family Medicine 49 years experience. read more Estrogen only: weakly to markedly proliferative endometrium, stromal breakdown, squamous morules Progestogen only: scant literature, secretory pattern (mildly tortuous glands with basal nuclei and scant luminal secretions) not always present Combined: Sequential: Weakly proliferative (small tubular glands with occasional mitoses) Endometrial Hyperplasia; An Update on Human Papillomavirus Vaccination in the United States; Effect of Second-Stage Pushing Timing on Postpartum Pelvic Floor Morbidity: A Randomized Controlled Trial; Permanent Compared With Absorbable Suture in Apical Prolapse Surgery: A Systematic Review and Meta-analysis Endometrial cancer is a common gynecological malignancy that can affect the uterus and other organs. During menopause, the ovaries produce fewer hormones, leading to a cessation of the menstrual cycle. read moreEndometrial Hyperplasia; An Update on Human Papillomavirus Vaccination in the United States; Effect of Second-Stage Pushing Timing on Postpartum Pelvic Floor Morbidity: A Randomized Controlled Trial; Permanent Compared With Absorbable Suture in Apical Prolapse Surgery: A Systematic Review and Meta-analysisUterine corpus cancer is the most prevalent gynecologic malignancy in American women with over 60,000 new cases expected during the next year and accounting for nearly 11,000 deaths. Metaplasia in Endometrium is a common benign condition that occurs in the glands of the endometrial lining (of the uterus). It is a normal finding in women of reproductive age. Common reasons for these procedures include: Abnormal (dysfunctional) uterine bleeding. During. They described functional endometrium as being “weakly proliferative” or “weakly. Initial evaluation — The primary goal in the diagnostic evaluation of postmenopausal patients with uterine bleeding is to exclude. A Verified Doctor answered. 0001) and had a higher body mass index (33. Applicable To. Objective In the last two decades, many reports demonstrated the unreliability of endometrial biopsy pathology showing an AH (atypical hyperplasia) to exclude a synchronous EEC (endometrioid endometrial carcinoma), with an underestimation of EEC in up to 50% of women. 10. Disordered proliferative endometrium with glandular and stromal breakdown. Weakly proliferative endometrium Normal proliferative endometrium Disordered proliferative Endometrial hyperplasia Asynchronously developed endometrium. This condition is detected through endometrial biopsy. is this something t?. Learn more about the causes, diagnosis, and treatment of this condition. Pediatrics 35 years experience. It is a normal finding in women of reproductive age. Looking for help on a biospy report: weakly proliferative. Regeneration of the endometrium following repair is an estrogen-dependent process, whereby the endometrium grows from a post-menstrual depth of 0. "Sections show background weakly proliferative endometrium with areas of metaplastic glands (eosinophilic, mucinous and tubal) which exhibit crowding and complex architecture, including cribriforming. Early detection and accurate diagnosis of these lesions and its precursor by endometrial cytology is now accepted in Japan and regarded as an effective primary method of evaluating endometrial pathology (atypical hyperplasia or carcinoma. However, in some instances, they cause pain, irregular bleeding, or infertility. 19,20 Early diagnosis of endometrial cancer types can help to save lives of the patients, and studies such as ours demonstrating the performance of weakly supervised learning methods on real-world data are key to. The proliferative endometrium is what is shed from the uterus when a woman has her cycle. In CPE, there are no specific clinical features that correlate with the intensity of pathologic findings; the most specific histologic feature is the presence of plasma cells, and it is predominantly identified in weakly proliferative endometrium. The endometrium is a sensitive target tissue for steroid sex hormones and is able to modify its structural characteristics with promptness and versatility. 10 ) [ 1 , 10 , 11 ]. For example, the endometrium in most term foetuses and neonates is only weakly proliferative, despite prolonged exposure to very high concentrations of unbound estrogens and progesterone in utero. The diagnosis is usually made after a small sample of tissue is removed from the endometrium during a procedure called an endometrial biopsy or uterine curetting. The immunohistochemical staining pattern for CD138 with appropriate controls supports the above diagnosis. Contrary to endometrial hyperplasia,. Most women (90%) with endometrial cancer develop symptomatic vaginal bleeding or discharge, and this is often what prompts them to seek gynecologic care. No hyperplasia or malignancy was observed. Inactive endometrium is normal in post menopausal women. No polarizing material was present in the granulomas, and. 09–7. the expression of Bcl-2 in the proliferative phase polyps in both the glandular epithelium and stroma compared with. 02 - other international versions of ICD-10 N85. Metaplasia in Endometrium is diagnosed by a pathologist on. In addition, the term “carcinoma in situ” was proposed to describe small lesions, with or. that is what weakly proliferative endometrium means. Definition. Definition focal overgrowth of localized benign endometrial tissue. Proliferative Endometrium in Menopause: To Treat or Not to Treat? Obstet Gynecol. Proliferative Endometrium Variably/haphazardly shaped glands (e. 2 percent) By comparison, the background prevalence of endometrial pathology in postmenopausal patients without bleeding is lower. Significance of benign endometrial cells in Pap smears from postmenopausal women. This highly regenerative capacity is likely driven by stem/progenitor cell populations that reside in the basalis. Endometrial receptivity describes the intricate process undertaken by the uterine lining to prepare for the implantation of an embryo. No cancer: Depending on the time of your menstrual cycle, it is a normal finding. BIOPSY. In the past, the terms “adenomatous hyperplasia” and “atypical hyperplasia” were used to denote proliferative lesions of the endometrium with varying degrees of architectural complexity and cytologic atypia [15, 32, 37, 70, 93]. Learn how we can help. Dr R. 81, p < 0. Normal: After menstruation is over the lining of the endometrium begins to proliferate and grow. An endometrial polyp is a usually noncancerous growth attached to the inner wall of the uterus, common for women undergoing or who have completed menopause. 2. In the 2003 World Health Organization. A menstrual cycle for one woman may last for a few days but for another woman may last a. 2 vs 64. 6 kg/m 2; P<. The immunohistochemical staining pattern for CD138 with appr. In this review, the criteria for adequacy and common artefacts in endometrial biopsies, as well as the interpretation of endometrial biopsies in general, are discussed,. 9 vs 30. Adenofibroma is a mixed tumor of the endometrium (and rarely also of the cervix) consisting of a benign epithelial and a benign mesenchymal component, both of which are integral components of the neoplasm. Chronic plasmacytic endometritis (CPE) is an infectious or reactive process with multiple etiologies. 1,758 satisfied customers. A: Low power view shows many morule formations in the endometrium. The clinical significance of EH lies in the associated risk of progression to endometrioid endometrial cancer (EC) and ‘atypical’ forms of EH are regarded as premalignant lesions. It is also the early proliferative phase and hence, a mixture of changes associated with menses and the early proliferative endometrium is seen . The functional layer thickens and then is shed during menstruation in humans and some other mammals, including apes, Old World. -- abundant neutrophils and blood. Learn how we can help. Definition and Classification. New blood vessels develop and the endometrial glands become bigger in size. Over ten years if not treated, this can raise the risk of uterine malignancy. Definition / general. endometrium, biopsy: - consistent with menstrual endometrium: -- stripped weakly proliferative endometrial glands. This was done in 3 parts: (1) retrospective chart review of all patients with reported insufficient or scant endometrial samples from 2010 to 2013 at our center to determine repeat sampling and final pathologic diagnosis; (2) survey of gynecologists about their practice for managing patients with these samples; (3) blind review of 99 cases of. Family Medicine 49 years experience. These symptoms can be uncomfortable and disruptive. Obstetrics and Gynecology 32 years experience. Exogenous hormones taken for various reasons may have an effect on the morphology of endometrium, endometrial stroma and myometrial lesions, such as leiomyomas. Created for people with ongoing healthcare needs but benefits everyone. Created for people with ongoing healthcare needs but benefits everyone. I. K. leiomyoma, other polypoid masses. However, adenomyosis can cause: Heavy or prolonged menstrual bleeding. The code is valid during the current fiscal year for the submission of HIPAA-covered transactions from October 01, 2023 through September 30, 2024. During the menstrual cycle, the endometrium grows under the influence of two major hormones – estrogen and progesterone. 04, 95% CI 2. smooth muscle cells blood vessels. Normal, no cancer,: but likely not ovulating, particularly if irregular or absent periods. [1] This imbalance in the hormonal milieu can be seen in a number of conditions where the cause of estrogen. 451 views Answered >2 years ago. 02 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The mean age for LG-ESS is 52 years, ranging between 16 and 83 years []. Endometrial biopsy was performed 3 to 4 weeks after completion of therapy to assess response. Blood. What does weakly proliferative endometrium mean. 04, 95% CI 2. Endometriosis is a condition where tissue similar to the lining of the womb grows in other places, such as the ovaries and fallopian tubes. The two biopsies showed a normal proliferative pattern endometrium. Read More. Hormonal or irritative stimuli are the main inducing factors of EMCs, although some metaplasias have a mutational origin. On pap tests this is associated with the classic double contoured balls of endometrial epithelium and stroma. Proliferative endometrium(15%) and secretory endometrium (5%) were identified in the postmenopausal women which is a comparable finding to other studies that reported a proliferative endometrium. Endometrial Stromal Nodule (ESN) and Low-Grade Endometrial Stromal Sarcoma (LG-ESS) ESN is a benign, whereas LG-ESS is a malignant neoplasm of the uterus (affecting the body of the uterus more than the cervix) and extra-uterine sites [8,9]. The study of endometrial carcinoma at menopause presents an interesting challenge. Results: After intervention in letrozole group, response to treatment was seen in 93% cases (including endometrial atrophy in 58. Early age at marriage and early sterilization also play a role. Absence of uterine bleeding. More African American women had a. proliferative endometrial glands (pseudostratified nuclei + mitoses) with focally abnormal glands (glands >2x normal size; irregular shape -- typically with inflection points; >4 glands involved (dilated)), +/-stromal condensation, gland-to-stromal ratio normal, not within an endometrial polyp. 5 years; P<. At the start of the menstrual cycle, the ovaries secrete the estrogen hormone, triggering the endometrium to enter a proliferative phase, during which it. Metaplasia is defined as a change of one cell type to another cell type. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE ENDOMETRIUM WITH FOCAL STROMAL AND/OR GLANDULAR BREAKDOWN. Definition / general. What does a weakly proliferative endometrium mean? It is probable that the presence of a weak proliferative pattern in a postmenopausal atrophic endometrium is a response of the uterine mucosa to continuous low level oestrogenic. A result of disordered or crowded glands is common with anovulatory cycles due to. N85. comment: sections show rare strips of inactive glandular epithelium? 2 doctor answers • 2 doctors weighed in. Then ovulation occurs. While secretory changes in endometrial glands can be observed occasionally at birth, decidual or menstrual changes are rare ( 25 ). Interestingly, presence of polyp tissue was associated with endometrial cancer outcome in both the unadjusted (univariate) and adjusted (multivariable) models (OR 4. The study of endometrial carcinoma at menopause presents an interesting challenge. Personal hx colorectal cancer Endometrial polyp Morbid obesity Presence of one or more factors, increases risk by 8 times. endometrium, biopsy: - consistent with menstrual phase endometrium: -- weakly proliferative endometrial glands with neutrophils and apoptosis.